Risk of hepatitis C progression in HIV-positive people

Acute infection (0-6 months)

In acute HCV only 20% people have any symptoms (fever, fatigue, loss of appetite, abdominal pain, nausea, vomiting, jaundice).

Up to 20% percent of HIV-positive people can clear hepatitis C without treatment in the first few months.

HCV TREATMENT OPTION: early treatment has a higher success rate

Most HIV-positive people go on to have chronic hepatitis C. HCV can progress more quickly in people who have been HIV+ for many years.

Up to 20% people do not develop any further significant liver damage

Chronic infection (6 months-30+ years)

Around 60% people develop mild to moderate liver scarring (fibrosis) and may experience symptoms, such as fatigue and depression.

HCV TREATMENT OPTION: treat before serious liver damage

Up to 40% people do not develop serious liver damage. HCV treatment is not always needed.

20-30% HIV-positive people may develop serious liver scarring (compensated cirrhosis) after 10-15 years. The liver can still function, despite damage.

HCV TREATMENT OPTION: treatment much less effective at this stage

1-5% of people with compensated cirrhosis develop liver cancer each year.

If cirrhosis progresses to decompensated liver disease a liver transplant is the only option.

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This is the web edition of the i-Base guide Hepatitis C for people living with HIV: testing, coinfection, treatment and support. This guide is available in UK clinics. You can order free printed copies or download a PDF version (657 Kb).

Information on this website is provided as a guide only. All treatment decisions should be taken in consultation with your doctor or other healthcare professional. Authors and credits. Full section index. Glossary.