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Home > Guides > Combination therapy > First-line drugs by class

Introduction to combination therapy - June 2008

Contents. New options in 2008. This pageFirst-line drugs by class Commonly used combinations.

First-line drugs by class

Types of HIV drugs

Combination nukes

Recommended:

  • Truvada (tenofovir + FTC)
  • Kivexa (abacavir + 3TC)

Alternative:

  • Combivir (AZT + 3TC)
  • Trizivir (abacavir + AZT + 3TC)

Single nukes

Recommended:

  • abacavir (Ziagen)
  • tenofovir (Viread)
  • 3TC (lamivudine, Epivir)
  • FTC (emtricitabine, Emtriva)

Alternative:

  • AZT (zidovudine, Retrovir)
  • ddI (didanosine, Videx)
  • d4T (stavudine, Zerit)

NNRTIs

Recommended:

  • efavirenz (Sustiva, Stocrin)

Alternative:

  • nevirapine (Viramune)

PIs

Recommended:

  • lopinavir/r (Kaletra)
  • fosamprenavir/r (Telzir)

Alternative:

  • atazanavir/r (Reyataz)
  • saquinavir/r (Invirase)
  • darunavir/r (Prezista) *
  • tipranavir/r (Aptivus) *
  • nelfinavir (Viracept)

EIs

Recommended:

  • none currently in first line

Alternative:

  • T-20 (Fuzeon) *
  • maraviroc (Celsentri) *

INIs

Recommended:

  • none currently in first line

Alternative:

  • raltegravir (Isentress) *

*Currently recommended for people with drug resistance.

Contents. New options in 2008. This pageFirst-line drugs by class Commonly used combinations.

This is the web edition of the i-Base guide Introduction to combination therapy. This guide is available in UK clinics. You can order free printed copies or download a PDF version (516 Kb). Translations. Authors and credits. Glossary. Full section index.

Decisions relating to your treatment should always be taken in consultation with your doctor. Information in this guide is intended to support those discussions.

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