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Introduction to combination therapy - June 2008

Non-standard approaches


Using two nukes plus either an NNRTI or a boosted PI has produced the most effective, durable and tolerable results for combination therapy. So far, we only have limited data on other approaches.

For example, some studies have not used nukes at all. These include either two boosted PIs, a single boosted PI, or a PI + NNRTI combination.

Although guidelines recommend a few standard combinations, treatment is individual. If one of the recommended combinations doesn't work for you, then it is important to know there are other treatment to switch to.


This is the web edition of the i-Base guide Introduction to combination therapy. This guide is available in UK clinics. You can order free printed copies or download a PDF version (516 Kb). Translations. Authors and credits. Glossary. Full section index.

Decisions relating to your treatment should always be taken in consultation with your doctor. Information in this guide is intended to support those discussions.

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