EDITORIAL

CONFERENCE REPORTS:
15th Conference on Retroviruses and Opportunistic Infections, 2-6 February 2008, Boston

• Introduction
• Increased risk of myocardial infarction associated with abacavir and ddI
• Position statement by the D:A:D steering committee

CONFERENCE REPORTS
38th World Conference on Lung Health of the Union against TB and Lung Disease, December 2007, Cape Town

• Treatment outcomes in patients who received rifampicin with nevirapine or efavirenz

CONFERENCE REPORTS
3rd International Workshop on Targeting HIV Entry, 7-9 December 2007, Washington DC

• CXCR4-using HIV found in 8.5% during early HIV infection
• Background drugs and low maraviroc levels explain resistance in Motivate studies

TREATMENT ACCESS

• Boehringer fails to register tipranavir in Brazil after using Brazilian patients in registrational studies
• FDA approval of generic ARVs

ANTIRETROVIRALS

• Raltegravir approved in Europe and available in the UK
• Paediatric lopinavir/r receives positive opinion from EMEA
• Etravirine (TMC-125) approved in the US
• Changes to atazanavir product label in the US
• US treatment guidelines updated
• HIV-positive adults with CD4 >500 cells/mm³ have similar mortality rates as the general population after seven years ARV treatment

RESISTANCE

• Dual-class mutations affecting RTI and NNRTI may be common in experienced patients

PREGNANCY AND PMTCT

• Atazanavir exposure in pregnancy
• Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-positive pregnant women

PAEDIATRICS

• Predictors of mortality in untreated HIV-positive children
• Pharmacokinetics of lopinavir/ritonavir in infants aged less than 12 months

HEPATITIS COINFECTION

• Comparative study of PEGIFN formulations in HCV monotherapy

IMMUNOLOGY AND BASIC SCIENCE

• Probing HIV’s dependence on host proteins
• An eye on the benign: pathogenesis lessons from non-pathogenic SIV infections
• HIV awakens retroviral zombies from cellular slumber
• Immune activation correlates with CD4 T cell declines in HIV controllers

DRUG INTERACTIONS

• Darunavir/ritonavir interaction with clarithromycin warrants caution
• Other updated and new resources on HIV drug interactions

ON THE WEB

• Conference reports
• Online journal articles
• Online medical resources

FUTURE MEETINGS

PUBLICATIONS AND SERVICES FROM i-BASE

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