EDITORIAL

CONFERENCE REPORTS:
14th Annual BHIVA Conference, 23–25 April 2008, Belfast

• Introduction
• Overview of MRC studies in 2008
• Initial results of BHIVA audit of HIV-related inpatient and day care in the UK
• Monitoring patients on antiretroviral therapy in resource-limited settings with viral load, CD4 count, or clinical observation alone
• Summary reports of other studies at BHIVA
• Effect of 100 mg ritonavir once- and twice-daily on lipids and cardiovascular markers in HIV-negative volunteers
• New-fill used to treat lipoatrophy in feet
• Use of fibroscan as non-invasive alternative to liver biopsy in HCV/HIV coinfection
• Choice of ARVs for people after organ transplantation
• Cases of ventricular tachycardia and atazanavir/r and methadone
• Lower reports of hyperbilirubinaemia in HCV-positive patients using atazanavir

CONFERENCE REPORTS: 15th Conference on Retroviruses and Opportunistic Infections (CROI), 2-6 February 2008, Boston

• Introduction

CROI: OPPORTUNISTIC INFECTIONS

• Immediate HAART reduces death and AIDS progression over 48 weeks in patients with acute OIs

CROI: TREATMENT ACCESS

• Utility of routine viral load, CD4 count and clinical monitoring among HIV-positive adults in rural Uganda
• Implementation of more complex regimens for prevention of mother-to-child transmission of HIV in Rwanda
• The estimated cost of switching from d4T to TDF in South Africa

CROI: WOMEN’S HEALTH

• Gender differences in viral load by CD4 count in men and women

CROI: PAEDIATRIC CARE

• Immune reconstitution inflammatory syndrome in young children initiating ART
• Complications with BCG vaccination in HIV-positive and negative infants: CHER Study
• The association between clinical characteristics and HIV-infection in very young infants
• Safety and efficacy of boosted darunavir in treatment-experienced children and adolescents at 24 weeks
• Responses to atazanavir-containing HAART in treatment-naïve children in South Africa
• Initial growth, CD4, and viral load responses to HAART in Ugandan compared to UK/Irish HIV-positive children
• Paediatric pharmacokinetic studies
• A pilot study of three treatment strategies for HIV-positive infants

TREATMENT ACCESS

• Key patient safety concern removed in new FDA guidance for non-US trials
• FDA approval of generic ARVs; first atazanavir approval

ANTIRETROVIRALS

• Tibotec issue Dear Doctor letter and FDA require darunavir label change relating to hepatotoxicity
• Draft BHIVA treatment guidelines online for comment
• Atazanavir 300mg capsule available in the UK
• Raltegravir approved in Scotland
• Abacavir, ddI and risk of heart attack: additional published data and regulatory announcements

PAEDIATRICS

• US paediatric guidelines updated
• New paediatric dosing recommendations for atazanavir

IMMUNOLOGY AND BASIC SCIENCE

• Understanding control of HIV replication in the absence of therapy
• A surreal, deeply troubling week for AIDS vaccine research

OTHER NEWS

• IAS calls for immediate release of Chinese activist
• Thailand’s war on drugs will undermine national AIDS fight and human rights: police given licence to kill drug users
• Activists criticise AIDS conference on opening day: Russian ban on substitution drug treatment is an ‘Iron Curtain’ to ARV treatment
• Opportunities for healthcare workers to volunteer overseas

ON THE WEB

• Conference reports and abstracts
• Community publications and resources
• Online medical resources
• Online full text articles

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