Metformin and exercise

Driscoll and colleagues reported that exercise training (one hour of aerobic plus strength training three times a week) together with metformin (850mg BID) significantly improved cardiovascular risk markers (waist-to-hip ratio, resting systolic and diastolic blood pressures and aerobic capacity to exercise) compared to metformin alone.[19]

The study population included 37 HIV-positive patients on HAART with hyperinsulinaemia or impaired glucose tolerance and waist-to-hip ratio >0.90 in men or >0.85 in women. Only 25 people completed the study, which unfortunately did not include an exercise-only arm. Diet did not change during the study.

	HIV Treatment Bulletin Vol 4 No7 August / September 2003